BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals

International Journal of Infectious Diseases

Chandrasekaran Padmapriyadarsini¹  Nathella Pavan Kumar²  Arul Nancy²  Rachel Mariam Renji²  Nandhini Selvaraj²  Subash Babu²  Anuradha Rajamanickam²  Srikanth Tripathy³  Bharathi Jeyadeepa³  Perumal Kannabiran Bhavani³  Dinesh Ashokan³  Vijayalakshmi Venkataramani³ 

[1] Corresponding authors: Nathella Pavan Kumar and Subash Babu, 1 Mayor Sathayamoorthy Road Chetpet, Chennai, 600031, India.;ICMR-National Institute for Research in Tuberculosis, Chennai, India;ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India;

关键词: BCG;    dendritic cells;    type I and III interferons;    COVID-19;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. Methods: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Results: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29. Conclusions: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses.

【 授权许可】

Unknown