An Investigation on the Pharmacological Profile of Titanium (IV) and Aluminum (III) 8-Hydroxyquinoline Derivatives Grafted on MCM-41 Mesoporous Silica

International Journal of Basic Science in Medicine

Samira Shahbazi¹  Gholamreza Shahhosseini¹  Yousef Fazaeli¹  Shahzad Feizi¹ 

[1] Nuclear Science and Technology Research Institute (NSTRI), Karaj, Iran;

关键词: MCM-41;    Titanium;    Aluminum;    8-hydroxyquinoline;    Anti-bacterial activity;    anti-fungal activity;   

DOI  :  10.15171/ijbsm.2018.22

来源: DOAJ

【 摘 要 】

Introduction: Regarding the increasing applications of nanomedicine in clinical practice, we aimed to assess the antibacterial and anti-fungal effects of nanocomposite complexes of titanium (IV) and aluminum (III).Methods: 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline were treated with titanium (IV) and Aluminum (III) alkoxide reagents to generate (Q)2 (2-BuO) Al (Q = 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline) and (Q)2 (O-i Pr)2 Ti (Q = 5-chloro-8-hydroxyquinoline) complexes. These active complexes were grafted on MCM-41 mesoporous silica in order to improve the overall toxicity and stability of them. Anti-bacterial and anti-fungal activities of the compounds were assessed.Results: The prepared materials were stable both under air and high temperature (at least up to 200°C). These nanocomposites were well dispersed in water. It was observed that (Q-Cl)2Ti@MCM-41 nanocomposite had anti-bacterial activity against Staphylococcus aureus at concentrations of 50, 75 and 120 ppm while at the 75, and 120 ppm concentrations against Escherichia coli and Salmonella typhi. The Q2Al@MCM-41 weakly inhibited the bacterial growth of E. coli at 75 and 120 ppm concentrations. (Q-Cl)2Al@MCM-41 did not show any antibacterial activity at any concentration. Moreover, (Q-Cl)2Ti@MCM-41 and (Q-Cl)2Al@MCM41 showed considerable anti-fungal activity against Saccharomyces cerevisiae at 50, 75, 120, and 150 ppm concentrations. The nanoparticles partly inhibited the growth of Kluyveromyces marxianus and Macrophomina phaseolina fungi at 150 ppm concentration.Conclusion: The results showed that the anti-microbial (bacterium and fungi) effect of the titanium and aluminum nanocomposite complexes can be improved in the solid state using appropriate chlorine substituent on the 8-hydroxyquinoline ligand and grafting to the mesoporous silica.

【 授权许可】

Unknown