期刊论文详细信息
Genome Biology
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Chad Tomlinson1  Irina Matetovici2  Aurelien Vigneron2  Serap Aksoy3  Brian L. Weiss4  Peter Takáč5  Rosemary Bateta6  Paul O. Mireji6  Veronika Michalkova7  Heather G. Marco8  David W. Farrow9  Emily C. Jennings9  Joshua B. Benoit9  Markus Friedrich1,10  Jelle Caers1,11  Liliane Schoofs1,11  Richard P. Meisel1,12  Anna R. Malacrida1,13  Grazia Savini1,13  Francesca Scolari1,13  Andrew J. Rosendale1,14  Rita Rio1,15  Wolfgang J. Miller1,16  Denis M. Larkin1,17  Matthew T. Weirauch1,18  Geoffrey M. Attardo1,19  Jan Van Den Abbeele2,20  Richard K. Wilson2,21  Jingwen Wang2,21  Daniel Lawson2,22  Lino Ometto2,23  Omar Rota-Stabelli2,23  Alvaro Acosta-Serrano2,24  Clair Rose2,24  Michael J. Lehane2,24  Irene Meki2,25  Kostas Bourtzis2,25  Adly M. M. Abd-Alla2,25  Andrew G. Parker2,25  Martin T. Swain2,26  Aurélie Hua-Van2,27  Guy Caljon2,28  Xin Zhao2,29  Patrick Minx2,29  Robert M. Waterhouse2,29  George Tsiamis2,29  Daniel Masiga3,30  Rosaline W. Macharia3,30  Wesley C. Warren3,31  Vasileios P. Lenis3,32  James E. Allen3,33  Gareth L. Maslen3,33  Ernesto Lowy-Gallego3,33  Mikkel B. Christensen3,33 
[1] Scientica, Ltd;Biomedical Sciences, Institute of Tropical Medicine;CAS Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences;Center for Autoimmune Genomics and Etiology and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital Medical Center;Department of Animal Systematics, Ústav zoológie SAV;Department of Biochemistry, Biotechnology Research Institute - Kenya Agricultural and Livestock Research Organization;Department of Biological Sciences, Florida International University;Department of Biological Sciences, University of Cape Town;Department of Biological Sciences, University of Cincinnati;Department of Biological Sciences, Wayne State University;Department of Biology - Functional Genomics and Proteomics Group, KU Leuven;Department of Biology and Biochemistry, University of Houston;Department of Biology and Biotechnology, University of Pavia;Department of Biology, Mount St. Joseph University;Department of Biology, West Virginia University;Department of Cell and Developmental Biology, Medical University of Vienna;Department of Comparative Biomedical Sciences, Royal Veterinary College;Department of Ecology & Evolution, Swiss Institute of Bioinformatics, University of Lausanne;Department of Entomology and Nematology, University of California, Davis;Department of Environmental and Natural Resources Management, University of Patras;Department of Epidemiology of Microbial Diseases, Yale School of Public Health;Department of Life Sciences, Imperial College London;Department of Sustainable Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach;Department of Vector Biology, Liverpool School of Tropical Medicine;Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food & Agriculture;Institute of Biological, Environmental and Rural Sciences, Aberystwyth University;Laboratoire Evolution, Genomes, Comportement, Ecologie, CNRS, IRD, Univ. Paris-Sud, Université Paris-Saclay;Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp;McDonnell Genome Institute, Washington University School of Medicine;Molecular Biology and Bioinformatics Unit, International Center for Insect Physiology and Ecology;School of Life Sciences, Fudan University;Schools of Medicine and Dentistry, University of Plymouth;VectorBase, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI);
关键词: Tsetse;    Trypanosomiasis;    Hematophagy;    Lactation;    Disease;    Neglected;   
DOI  :  10.1186/s13059-019-1768-2
来源: DOAJ
【 摘 要 】

Abstract Background Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Results Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges. Conclusions Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.

【 授权许可】

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