The Cerebral Arterial Wall in the Development and Growth of Intracranial Aneurysms

Applied Sciences

Katsuhiro Mizutani¹  Vincent Vauclin²  Federico Di Maria²  Pasquale Marco Abbate²  Alice Venier²  Alessandro Sgreccia²  A. T. M. Hasibul Hasan²  Arturo Consoli²  Silvia Pizzuto²  Georges Rodesch²  Oguzhan Coskun² 

[1] Department of Neurosurgery, School of Medicine, Keio University, Tokyo 160-8582, Japan;Diagnostic and Interventional Neuroradiology Department, Foch Hospital, 92150 Suresnes, France;

关键词: intracranial aneurysm;    arterial wall;    hemodynamics;   

DOI  :  10.3390/app12125964

来源: DOAJ

【 摘 要 】

A considerable number of people harbor intracranial aneurysms (IA), which is a focal or segmental disease of the arterial wall. The pathophysiologic mechanisms of IAs formation, growth, and rupture are complex. The mechanism also differs with respect to the type of aneurysm. In broad aspects, aneurysms may be considered a disease of the vessel wall. In addition to the classic risk factors and the genetic/environmental conditions, altered structural and pathologic events along with the interaction of the surrounding environment and luminal flow dynamics contribute to the aneurysm’s development and growth. In this review, we have tried to simplify the complex interaction of a multitude of events in relation to vessel wall in the formation and growth of IAs.

【 授权许可】

Unknown