Effects of iodinated contrast media in a novel model for cerebral vasospasm

Arquivos de Neuro-Psiquiatria

Tatiana Nikitina¹  Olga Zavaritskaya¹  Vladimir Semenyutin¹  Pontus B. Persson¹  Andreas Patzak¹  Mauricio Sendeski¹ 

关键词: brain ischemia;    cerebral angiography;    contrast media;    hemodynamics;    intracranial aneurysm;    intracranial vasospasm;    subarachnoid hemorrhage;    isquemia cerebral;    angiografia cerebral;    meio de contraste;    hemodinâmica;    aneurisma intracraniano;    vasoespasmo intracraniano;    hemorragia subaracnóide;   

DOI  :  10.1590/0004-282X20140222

来源: SciELO

【 摘 要 】

Objective We developed an in vitro model for vasospasm post subarachnoid hemorrhage that was suitable for investigating brain vessel autoregulation. We further investigated the effects of iodinated contrast medium on the vascular tone and the myogenic response of spastic cerebral vessels. Method We isolated and perfused the superior cerebellar arteries of rats. The vessels were pressurized and studied under isobaric conditions. Coagulated blood was used to simulate subarachnoid hemorrhage. The contrast medium iodixanol was applied intraluminally. Results Vessels exposed to blood developed significantly stronger myogenic tone (65.7 ± 2.0% vs 77.1 ± 1.2% of the maximum diameter, for the blood and the control group, respectively) and significantly decreased myogenic response, compared with the control groups. The contrast medium did not worsen the myogenic tone or the myogenic response in any group. Conclusion Our results show that deranged myogenic response may contribute to cerebral blood flow disturbances subsequent to subarachnoid hemorrhage. The contrast medium did not have any negative influence on vessel tone or myogenic response in this experimental setting.

【 授权许可】

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