Networks Disrupted in Linguistic Variants of Frontotemporal Dementia

Frontiers in Neurology

Andrea del Pilar Rueda¹  Diana L. Matallana²  Pablo Alexander Reyes²  Felipe Uriza³ 

[1] BASPI, Faculty of Engineering, Pontificia Universidad Javeriana, Bogotá, Colombia;Medicine School, Aging Institute, Pontificia Universidad Javeriana, Bogotá, Colombia;Radiology Department, Hospital Universitario San Ignacio, Bogotá, Colombia;

关键词: diffusion tensor imaging;    primary progressive aphasia;    frontotemporal dementia;    fractional anisotropy;    white matter;    structural connectivity;   

DOI  :  10.3389/fneur.2019.00903

来源: DOAJ

【 摘 要 】

The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy patterns of white matter in each variant. Twenty patients with svPPA, 20 patients with nfvPPA, 26 patients with behavioral variant of FTD (bvFTD) and, 33 controls were included. An analysis based on the connectivity of structural networks showed changes in FA and MD in svPPA and nfvPPA with respect to bvFTD. Much damage in the internal networks of the left temporal lobe was found in svPPA patients; in contrast, patients with nfvPPA showed atrophy in networks from the basal ganglia to motor and premotor areas. Those findings support the dual stream model of speech and language.

【 授权许可】

Unknown