MicroRNAs in Alzheimer’s Disease: Function and Potential Applications as Diagnostic Biomarkers

Frontiers in Molecular Neuroscience

Hao Li¹  Yu Cao¹  Ting-Ting Zhang¹  Li-Na Ma¹  Wei Wei¹  Zhi-Yong Wang¹ 

[1] Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China;

关键词: microRNAs;    Alzheimer’s disease;    pathogenesis;    diagnosis;    biomarker;   

DOI  :  10.3389/fnmol.2020.00160

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is the most common form of dementia. Although the incidence of AD is high, the rates of diagnosis and treatment are relatively low. Moreover, effective means for the diagnosis and treatment of AD are still lacking. MicroRNAs (miRNAs, miRs) are non-coding RNAs that play regulatory roles by targeting mRNAs. The expression of miRNAs is conserved, temporal, and tissue-specific. Impairment of microRNA function is closely related to AD pathogenesis, including the beta-amyloid and tau hallmarks of AD, and there is evidence that the expression of some microRNAs differs significantly between healthy people and AD patients. These properties of miRNAs endow them with potential diagnostic and therapeutic value in the treatment of this debilitating disease. This review provides comprehensive information about the regulatory function of miRNAs in AD, as well as potential applications as diagnostic biomarkers.

【 授权许可】

Unknown