Utilization of Acidic α-Amino Acids as Acyl Donors:An Effective Stereo-Controllable Synthesis of Aryl-Ketoα-Amino Acids and Their Derivatives

Molecules

Takuma Yoshida¹  Zetryana Puteri Tachrim¹  Lei Wang¹  Makoto Hashimoto¹  Masashi Okamoto¹  Yasuyuki Hashidoko¹  Yuta Murai² 

[1] Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo 060-8589, Japan;Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo 001-0021, Japan;

关键词: aryl-keto α-amino acid;    Friedel-Crafts acylation;    Lewis acid;    triflic acid;   

DOI  :  10.3390/molecules19056349

来源: DOAJ

【 摘 要 】

Aryl-keto-containing α-amino acids are of great importance in organicchemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives.In this review, we summarize the preparation of aryl-keto containing α-amino acids byFriedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts.

【 授权许可】

Unknown