MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

Cancer Cell International

Mehdi Abbasi¹  Atefe Alaee²  Habib-o-Lah Gorgani³  Mehdi Moghtadaei³  Hossein Farahini³  Bahram Boddouhi³  Shayan Hosseinzadeh⁴  Peyman Kaghazian⁵  Babak Otoukesh⁶ 

[1] Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences;Department of Information Sciences, Tehran University of Medical Sciences;Department of Orthopedic Surgery, Bone and Joint Reconstruction Research Center, Iran University of Medical Science;Department of Orthopedic Surgery, Boston Children’s Hospital, Harvard Medical School;Department of Orthopedic and Traumatology, Universitätsklinikum Bonn;Orthopedic Surgery Fellowship in Département Hospitalo-Universitaire MAMUTH « Maladies musculo-squelettiques et innovations thérapeutiques » , Université Pierre et Marie-Curie, Sorbonne Université;

关键词: MicroRNAs;    Osteosarcoma;    Targets;    Therapy;   

DOI  :  10.1186/s12935-020-01342-4

来源: DOAJ

【 摘 要 】

Abstract MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.

【 授权许可】

Unknown