Hydroxyapatite for Biomedical Applications: A Short Overview

Ceramics

Elisa Fiume¹  Francesco Baino¹  Giulia Magnaterra¹  Enrica Verné¹  Abbas Rahdar² 

[1] Department of Applied Science and Technology (DISAT), Institute of Materials Physics and Engineering, Politecnico di Torino, 10129 Turin, Italy;Department of Physics, University of Zabol, Zabol 98613-35856, Iran;

关键词: bioceramics;    calcium phosphate;    hydroxyapatite;    bone;    tissue engineering;   

DOI  :  10.3390/ceramics4040039

来源: DOAJ

【 摘 要 】

Calcium phosphates (CaPs) are biocompatible and biodegradable materials showing a great promise in bone regeneration as good alternative to the use of auto- and allografts to guide and support tissue regeneration in critically-sized bone defects. This can be certainly attributed to their similarity to the mineral phase of natural bone. Among CaPs, hydroxyapatite (HA) deserves a special attention as it, actually is the main inorganic component of bone tissue. This review offers a comprehensive overview of past and current trends in the use of HA as grafting material, with a focus on manufacturing strategies and their effect on the mechanical properties of the final products. Recent advances in materials processing allowed the production of HA-based grafts in different forms, thus meeting the requirements for a range of clinical applications and achieving enthusiastic results both in vitro and in vivo. Furthermore, the growing interest in the optimization of three-dimensional (3D) porous grafts, mimicking the trabecular architecture of human bone, has opened up new challenges in the development of bone-like scaffolds showing suitable mechanical performances for potential use in load bearing anatomical sites.

【 授权许可】

Unknown