Tractography methods and findings in brain tumors and traumatic brain injury

NeuroImage

Dhiego Chaves de Almeida Bastos¹  Andrei Irimia²  Fang-Cheng Yeh³  Alexandra J. Golby⁴ 

[1] Corresponding author at: Department of Neurological Surgery, UPMC Presbyterian, Suite B-400, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.;Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA;Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA;

关键词: Diffusion MRI;    fiber tracking;    tractography;    brain tumor;    glioma;    traumatic brain injury;   

DOI  :  

来源: DOAJ

【 摘 要 】

White matter fiber tracking using diffusion magnetic resonance imaging (dMRI) provides a noninvasive approach to map brain connections, but improving anatomical accuracy has been a significant challenge since the birth of tractography methods. Utilizing tractography in brain studies therefore requires understanding of its technical limitations to avoid shortcomings and pitfalls. This review explores tractography limitations and how different white matter pathways pose different challenges to fiber tracking methodologies. We summarize the pros and cons of commonly-used methods, aiming to inform how tractography and its related analysis may lead to questionable results. Extending these experiences, we review the clinical utilization of tractography in patients with brain tumors and traumatic brain injury, starting from tensor-based tractography to more advanced methods. We discuss current limitations and highlight novel approaches in the context of these two conditions to inform future tractography developments.

【 授权许可】

Unknown