Cerebral Connectivity and High-grade Gliomas: Evolving Concepts of Eloquent Brain in Surgery for Glioma

AIMS Medical Science

article

Sanjay Konakondla¹  Steven A. Toms¹ 

[1] Geisinger Health System;Rhode Island Hospital

关键词: cerebral connectivity;    diffusion tensor imaging;    fiber tracking;    gliomas;    intraoperative monitoring;    ;   

DOI  :  10.3934/medsci.2017.1.52

来源: American Institute of Mathematical Sciences

【 摘 要 】

Technological advances in imaging the human brain help us map and understand the intricacies of cerebral connectivity. Current techniques and specific imaging sequences, however, do come with limitations. Image resolution, variability of techniques and interpretation of images across institutions are just a few concerns. In the setting of high-grade gliomas, understanding how these pathways are affected during tumor growth, surgical resection, and in the brain plasticity presents an even greater challenge. Clinical symptoms, tumor growth, and intraoperative electrical stimulation are important peri-operative considerations to assist in determining neuronal re-wiring and establish a basis of anatomic and functional correlation. The application of functional mapping coupled with the understanding of the natural history of gliomas and implications of neural plasticity, is critical in achieving the goals of maximal tumor resection while minimizing post operative deficits and improving quality of life.

【 授权许可】

CC BY