Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

International Journal of Molecular Sciences

Maria S. Syrovatkina¹  Aleksandr S. Krasichkov²  Maria S. Istomina³  Galina A. Shulmeyster³  Victor N. Postnov³  Natalia V. Evreinova³  Michael M. Galagudza³  Ilia V. Aleksandrov³  Dmitry V. Korolev³ 

[1] Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”, 5 Professora Popova Street, 197376 Saint Petersburg, Russia;Department of Radio Engineering Systems, Saint Petersburg Electrotechnical University “LETI”, 5 Professora Popova Street, 197376 Saint Petersburg, Russia;Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia;

关键词: theranostics;    multilayer nanoparticles;    magnetic nanoparticles;    silica nanoparticles;    chitosan;    quinacrine;   

DOI  :  10.3390/ijms23020932

来源: DOAJ

【 摘 要 】

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS₂/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

【 授权许可】

Unknown