Whither Magnetic Hyperthermia? A Tentative Roadmap

Materials

卷:14

EleniK. Efthimiadou¹  MaximilianO. Besenhard²  Maríadel Puerto Morales³  Sabino Veintemillas-Verdaguer³  Quentin Harmer⁴  Eric Mayes⁴  Simo Spassov⁵  Antonio Santana-Otero⁶  FranciscoJ. Teran⁶  Irene Rubia-Rodríguez⁶  Daniel Ortega⁶  Ángel Millán⁷  Yuanyu Gu⁷  PatriciaDe La Presa⁸  Claire Wilhelm⁹  Florence Gazeau⁹  Patrick Goodwill¹⁰  James Mansfield¹⁰  Jeff Gaudet¹⁰  James Wells¹¹  Uwe Steinhoff¹¹  Frank Wiekhorst¹¹  Christer Johansson¹²  Etelka Tombácz¹³  StefaanJ. Soenen¹⁴  BellaB. Manshian¹⁴  NguyenT. K. Thanh¹⁵ 

[1] Chemistry Department, Inorganic Chemistry Laboratory, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece;

[2] Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK;

[3] Department of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM/CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain;

[4] Endomag, The Jeffreys Building, St John’s Innovation Park, Cowley Road, Cambridge CB4 0WS, UK;

[5] Geophysical Centre of the Royal Meteorological Institute, 1 rue du Centre Physique, 5670 Dourbes, Belgium;

[6] IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain;

[7] INMA Instituto de Nanociencia de Materiales de Aragón, Pedro Cerbuna 12, 50009 Zaragoza, Spain;

[8] Instituto de Magnetismo Aplicado UCM-ADIF-CSIC, A6 22,500 km, 29260 Las Rozas, Spain;

[9] Laboratoire Matière et Systèmes Complexes MSC, Université de Paris/CNRS, 75013 Paris, France;

[10] Magnetic Insight, Alameda, CA 94501, USA;

[11] Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany;

[12] RISE Research Institutes of Sweden, Sensors and Materials, Arvid Hedvalls Backe 4, 411 33 Göteborg, Sweden;

[13] Soós Water Technology Research and Development Center, University of Pannonia, 8200 Nagykanizsa, Hungary;

[14] Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, Biomedical Sciences Group, B-3000 Leuven, Belgium;

[15] UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK;

关键词: magnetic hyperthermia;    magnetic nanoparticles;    hysteresis losses;    cancer;    magnetic particle imaging;    theranostics;   

DOI  :  10.3390/ma14040706

来源: DOAJ

【 摘 要 】

The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.

【 授权许可】

Unknown