Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review

International Journal of Molecular Sciences

Sara Giannoni¹  Gabriele Siciliano¹  Gabriele Bellini¹  Giovanni Palermo¹  Roberto Ceravolo¹ 

[1] Unit of Neurology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy;

关键词: biomarkers;    dopamine transporter;    SPECT;    nigrostriatal pathway;   

DOI  :  10.3390/ijms222011234

来源: DOAJ

【 摘 要 】

A major goal of current clinical research in Parkinson’s disease (PD) is the validation and standardization of biomarkers enabling early diagnosis, predicting outcomes, understanding PD pathophysiology, and demonstrating target engagement in clinical trials. Molecular imaging with specific dopamine-related tracers offers a practical indirect imaging biomarker of PD, serving as a powerful tool to assess the status of presynaptic nigrostriatal terminals. In this review we provide an update on the dopamine transporter (DAT) imaging in PD and translate recent findings to potentially valuable clinical practice applications. The role of DAT imaging as diagnostic, preclinical and predictive biomarker is discussed, especially in view of recent evidence questioning the incontrovertible correlation between striatal DAT binding and nigral cell or axon counts.

【 授权许可】

Unknown