Amelioration of complete Freund’s adjuvant-induced arthritis by Calotropis procera latex in rats

Future Journal of Pharmaceutical Sciences

Roshni Patel¹  Gaurang Shah²  Shrikalp Deshpande³  Shahrukh Kadri³  Priyanshee Gohil³ 

[1] Department of Pharmacology and Pharmacy Practice, K. B. Institute of Pharmaceutical Education and Research;Department of Pharmacology, L. M. College of Pharmacy;Department of Pharmacovigilance, Lambda Therapeutic Research Ltd.;

关键词: Latex;    Calotropis procera;    Rheumatoid arthritis;    Complete Freund’s adjuvant;    Functional parameters;    ELISA;   

DOI  :  10.1186/s43094-021-00361-w

来源: DOAJ

【 摘 要 】

Abstract Background Rheumatoid arthritis is the most common cause of disability, affecting 0.3–1% of the adult population worldwide. The latex of Calotropis procera possesses potent anti-inflammatory as well as analgesic properties. In light above facts, the present study was designed to evaluate anti-arthritic activity of Calotropis procera latex in complete Freund's adjuvant (CFA)-induced arthritis in Wistar albino rats. Complete Freund's adjuvant was injected into the left hind paw on day 0, and treatment of prednisolone and Calotropis procera latex was given from day 0 to 28. Various biochemical, hematological and functional parameters as well as radiological and histopathological changes of joint along with body weight and paw volume were measured. Results Calotropis procera treatment significantly lowered paw volume in CFA-induced arthritic rats. Significant improvement was observed in functional, biochemical and hematological parameters in Calotropis procera-treated rats. However, the body weight remained unaffected. Histological and radiographical examination of synovial joints in Calotropis procera-treated animals exhibited less synovial hyperplasia, infiltration and accumulation of inflammatory cell in synovial fluid, cartilage and bone erosion and joint space narrowing. Conclusion Calotropis procera latex possesses anti-arthritic activity, which is facilitated by modulation in the level of inflammatory mediators and oxidative stress. The improvement in hematological as well as biochemical parameters might be reflected on functional, histopathological, radiological changes and thereby disease progression.

【 授权许可】

Unknown