The Biological Activity of Monarda didyma L. Essential Oil and Its Effect as a Diet Supplement in Mice and Broiler Chicken

Molecules

Alexis St-Gelais¹  Jean Legault²  Héloïse Côté²  André Pichette² 

[1] Laboratoire PhytoChemia Inc., 628 Boul. du Saguenay Ouest, Saguenay, QC G7J 1H4, Canada;Laboratoire d’Analyse et de Séparation des Essences Végétales, Université du Québec à Chicoutimi, 555 boulevard de l’Université, Chicoutimi, QC G7H 2B1, Canada;

关键词: Monarda didyma;    antibacterial activity;    essential oil;    broiler;    mouse;   

DOI  :  10.3390/molecules26113368

来源: DOAJ

【 摘 要 】

The use of growth-promoting antibiotics in livestock faces increasing scrutiny and opposition due to concerns about the increased occurrence of antibiotic-resistant bacteria. Alternative solutions are being sought, and plants of Lamiaceae may provide an alternative to synthetic antibiotics in animal nutrition. In this study, we extracted essential oil from Monarda didyma, a member of the Lamiaceae family. We examined the chemical composition of the essential oil and then evaluated the antibacterial, antioxidant, and anti-inflammatory activities of M. didyma essential oil and its main compounds in vitro. We then evaluated the effectiveness of M. didyma essential oil in regard to growth performance, feed efficiency, and mortality in both mice and broilers. Carvacrol (49.03%) was the dominant compound in the essential oil extracts. M. didyma essential oil demonstrated antibacterial properties against Escherichia coli (MIC = 87 µg·mL⁻¹), Staphylococcus aureus (MIC = 47 µg·mL⁻¹), and Clostridium perfringens (MIC = 35 µg·mL⁻¹). Supplementing the diet of mice with essential oil at a concentration of 0.1% significantly increased body weight (+5.4%) and feed efficiency (+18.85%). In broilers, M. didyma essential oil significantly improved body weight gain (2.64%). Our results suggest that adding M. didyma essential oil to the diet of broilers offers a potential substitute for antibiotic growth promoters.

【 授权许可】

Unknown