A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

Molecules

Sam Fong Yau Li¹  Anwei Ding²  Sheng Yu²  Sheng Guo²  Qinan Wu²  Mingqiu Shan²  Hui Yan²  Li Zhang²  Zhenzhong Wang³  Wei Xiao³ 

[1] Department of Chemistry, National University of Singapore, Singapore 117543, Singapore;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China;National Key Laboratory of Pharmaceutical New Technology for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China;

关键词: geniposide;    iridoid glycoside;    natural product;    pharmacokinetics;    pharmacology;    phytochemistry;    toxicology;   

DOI  :  10.3390/molecules22101689

来源: DOAJ

【 摘 要 】

Iridoid glycosides are natural products occurring widely in many herbal plants. Geniposide (C17H24O10) is a well-known one, present in nearly 40 species belonging to various families, especially the Rubiaceae. Along with this herbal component, dozens of its natural derivatives have also been isolated and characterized by researchers. Furthermore, a large body of pharmacological evidence has proved the various biological activities of geniposide, such as anti-inflammatory, anti-oxidative, anti-diabetic, neuroprotective, hepatoprotective, cholagogic effects and so on. However, there have been some research articles on its toxicity in recent years. Therefore, this review paper aims to provide the researchers with a comprehensive profile of geniposide on its phytochemistry, pharmacology, pharmacokinetics and toxicology in order to highlight some present issues and future perspectives as well as to help us develop and utilize this iridoid glycoside more efficiently and safely.

【 授权许可】

Unknown