Endocannabinoids as Guardians of Metastasis

International Journal of Molecular Sciences

Irmgard Tegeder¹ 

[1] Institute of Clinical Pharmacology, University Hospital Frankfurt, Germany;

关键词: endocannabinoids;    anandamide;    2-arachidonoylglycerol;    orphan G-protein coupled receptor;    immune cells;    angiogenesis;   

DOI  :  10.3390/ijms17020230

来源: DOAJ

【 摘 要 】

Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.

【 授权许可】

Unknown