Endocannabinoids, Related Compounds and Their Metabolic Routes

Molecules

Filomena Fezza³  Monica Bari³  Rita Florio¹  Emanuela Talamonti⁴  Monica Feole³  Mauro Maccarrone² 

[1] Department of Movement, Human and Health Sciences, Foro Italico University of Rome, 00128 Rome, Italy; E-Mail:;European Center for Brain Research/IRCCS Santa Lucia Foundation, 00143 Rome, Italy;Department of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy; E-Mails:;Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; E-Mail:

关键词: anandamide;    2-arachidonoylglycerol;    endocannabinoid metabolic routes;    fatty acids;   

DOI  :  10.3390/molecules191117078

来源: mdpi

【 摘 要 】

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ⁹-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.