A Pan-Cancer Analysis of Tumor-Infiltrating B Cell Repertoires

Frontiers in Immunology

Akshay Ravoor¹  Marina Sirota²  Katharine Yu²  Silvia Pineda³  Núria Malats³ 

[1] Bakar Computational Health Sciences Institute, University of California, San Francisco (UCSF), San Francisco, CA, United States;Department of Pediatrics, University of California, San Francisco (UCSF), San Francisco, CA, United States;Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), and Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain;

关键词: B cell repertoire;    immune repertoire;    tumor microenvironment;    tumor infiltration;    TCGA;   

DOI  :  10.3389/fimmu.2021.790119

来源: DOAJ

【 摘 要 】

Tumor-infiltrating B cells can play an important role in anti-tumor responses but their presence is not well understood. In this study, we extracted the B cell receptor repertoires from 9522 tumor and adjacent non-tumor samples across 28 tumor types in the Cancer Genome Atlas project and performed diversity and network analysis. We identified differences in diversity and network statistics across tumor types and subtypes and observed a trend towards increased clonality in primary tumors compared to adjacent non-tumor tissues. We also found significant associations between the repertoire features and mutation load, tumor stage, and age. Our V-gene usage analysis identified similar V-gene usage patterns in colorectal and endometrial cancers. Lastly, we evaluated the prognostic value of the repertoire features and identified significant associations with survival in seven tumor types. This study warrants further research into better understanding the role of tumor-infiltrating B cells across a wide range of tumor types.

【 授权许可】

Unknown