Sex Specific Expression of Interleukin 7, 8 and 15 in Placentas of Women with Gestational Diabetes

International Journal of Molecular Sciences

Christina Kuhn¹  Thomas Kolben²  TheresaM. Kolben²  Udo Jeschke²  Sven Mahner²  Simon Keckstein²  Susanne Beyer²  Magdalena Jegen²  Julia Knabl²  Sarah Meister²  Sophia Pritz²  Stefan Hutter²  Niklas Amann² 

[1] Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany;Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany;

关键词: cytokines;    gestational diabetes;    placenta;    trophoblast;    decidua;   

DOI  :  10.3390/ijms21218026

来源: DOAJ

【 摘 要 】

Gestational diabetes mellitus (GDM) is known to increase the risk for feto-maternal complications during pregnancy. A state of low-grade inflammation, with elevated levels of proinflammatory molecules, similar to patients with obesity or diabetes mellitus type 2 has also been partly described in GDM. The placenta, as unique interface between mother and fetus, is not only passively affected by changes in one of these organisms, but also acts as a modulator by expressing hormones and cytokines. This study aimed to investigate the expression of the proinflammatory cytokines Interleukin (IL) 7, 8 and 15 in GDM in placental tissue. A total number of 80 placentas were included (40 GDM/40 control group). The expression of IL-7, 8 and 15 was investigated in extravillous trophoblast (EVT) and syncytiotrophoblast (SCT) by immunohistochemistry and immunofluorescence double staining. The immunohistochemical staining was evaluated with the semiquanitfied immunoreactive score (IRS). While the expression IL-15 was significantly upregulated in EVTs of women with GDM. The expression of IL-8 was significantly decreased in EVT of the GDM group. Furthermore, significant fetal sex specific differences were detectable in all three cytokines. Our findings suggest an involvement of the investigated cytokines in the maintenance of a state of chronic low-grade inflammation on placental level in patients suffering from GDM.

【 授权许可】

Unknown