Septotemporal variation in beta-adrenergic modulation of short-term dynamics in the hippocampus

IBRO Neuroscience Reports

Costas Papatheodoropoulos¹  George Trompoukis²  Athina Miliou²  Vassilis Papaleonidopoulos² 

[1] Correspondence to: Laboratory of Physiology, Dept of Medicine, University of Patras, 26504 Rion, Greece.;Laboratory of Neurophysiology, Department of Medicine, University of Patras, Rion, Greece;

关键词: Hippocampus;    Short-term plasticity;    Neuronal excitation;    Noradrenaline;    Beta-adrenergic receptor;    Dorsal-ventral axis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Recent evidence shows a greater facilitating effect of beta-adrenergic receptors (β-ARs) on long-term synaptic plasticity in the ventral versus the dorsal hippocampus. Here, using field potentials from the CA1 area and a ten-pulse stimulation train of varying frequency we show that activation of β-ARs by isoproterenol preferentially facilitates the output from the dorsal hippocampus at the frequency range of 3–40 Hz without affecting short-term synaptic plasticity. Furthermore, isoproterenol increases basal synaptic transmission in the dorsal hippocampus only and enhances basal neuronal excitation more in the dorsal than the ventral hippocampus. These results suggest that β-AR-modulation of short-term neuronal dynamics differs along the longitudinal axis of the hippocampus, thereby contributing to functional specialization along the same axis.

【 授权许可】

Unknown