Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice

Polymers

Rosa Rodriguez-Fernández¹  Mariángeles Muñoz-Fernández²  Rafael Ceña-Diez²  Maria Jesús Serramia²  Ignacio Rodriguez-Izquierdo²  Isidoro Martínez³ 

[1] Hospital de Pediatría, Gregorio Marañón University General Hospital (HGUGM), Gregorio Marañón Health Research Institute (IiSGM), C/Dr. Esquerdo 46, 28007 Madrid, Spain;Immunology Section, Head Inmuno-Biology Molecular Laboratory, Gregorio Marañón University General Hospital (HGUGM), Gregorio Marañón Health Research Institute (IiSGM), 28007 Madrid, Spain;Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28007 Madrid, Spain;

关键词: RSV infection;    G2-S16 dendrimer;    syncytium;    nanotechnology;   

DOI  :  10.3390/polym13132141

来源: DOAJ

【 摘 要 】

The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection.

【 授权许可】

Unknown