Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

Frontiers in Physiology

Nikolaos Fountoulakis¹  Emil Fraenkel²  Jūratė Zupkauskienė³  Petras Navickas³  Keith D. Rochfort⁴  Eugenia Gkaliagkousi⁵  Antonios Lazaridis⁵  Agnė Šatrauskienė⁶  Dimitrios Terentes-Printzios⁷  János Nemcsik⁹  M. Rosa Bernal-Lopez^1,10  Kristina R. Gopcevic^1,11  Rachel E. Climie^1,13  Rosa M. Bruno^1,14  Ömür Acet^1,15 

[1] 0Faculty of Life Sciences and Medicine, King’s College London - Waterloo Campus, London, United Kingdom;11st Department of Internal Medicine, University Hospital and Pavol Jozef Šafárik University in Košice, Košice, Slovakia;2Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania;3School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland;3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;4Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania;5First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece;Department of Family Medicine, Semmelweis University, Budapest, Hungary;Health Service of ZUGLO, Department of Family Medicine, Budapest, Hungary;Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigacion Biomedica de Malaga, University of Malaga, CIBER Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Málaga, Spain;Laboratory for Analytics of Biomolecules, Department of Chemistry in Medicine, Faculty of Medicine, Belgrade, Serbia;Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia;Sports Cardiology Lab, Clinical Research Domain, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;Unversite de Paris, INSERM, U970, Paris Cardiovascular Research Center, Paris, France;Vocational School of Health Science, Pharmacy Services Program, Tarsus University, Tarsus, Turkey;

关键词: vascular aging;    circulating biomarkers;    oxidative stress;    inflammation;    cellular matrix;    epigenetics;   

DOI  :  10.3389/fphys.2021.789690

来源: DOAJ

【 摘 要 】

Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.

【 授权许可】

Unknown