Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms

Cancer Cell International

Russel J. Reiter¹  Hamed Mirzaei²  Zatollah Asemi²  Mohadese Honari²  Rana Shafabakhsh² 

[1] Department of Cellular and Structural Biology, University of Texas Health Science, Center;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences;

关键词: Colorectal cancer;    Resveratrol;    Anti-inflammatory;    Anti-oncotic;   

DOI  :  10.1186/s12935-019-0906-y

来源: DOAJ

【 摘 要 】

Abstract Colorectal cancer (CRC) is the third most common cancer and one of the main causes of cancer death entire the world. Environmental, dietary, and lifestyle factors including red meat consumption, cigarette smoking, alcohol intake and family history are the most important risk factors of CRC. Multiple pathways including inflammation, oxidative stress, and apoptosis are involved in its incidence and progression. Resveratrol, a polyphenolic compound, has different pharmacologic functions including anti-inflammation, cancer prevention, lipid-lowering effect, and hypoglycemic effect. Many studies have proved that resveratrol might also represent a chemo preventive effect on CRC. Thus, the aim of the current review is to depict the role of resveratrol in treatment of CRC in a molecular manner.

【 授权许可】

Unknown