Octodrine: New Questions and Challenges in Sport Supplements

Brain Sciences

Giovanni Martinotti¹  Mire Zloh²  Ornella Corazza²  Ahmed Al-Imam³  Yasmine Elgharably⁴  Shanna Marrinan⁵  Valeria Catalani⁶  Robert Chilcott⁶  Mariya Prilutskaya⁷ 

[1] Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University, 66100 Chieti, Italy;Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB, UK;Faculty of Medicine, University of Baghdad, Baghdad 10071, Iraq;Navy General Hospital, Cardiovascular department, Alexandria 21513, Egypt;Parliamentary Office of Science and Technology, Houses of Parliament, London SW1A 0AA, UK;Research Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Herts SP9 11FA, UK;Semey State Medical University, Republican Scientific and Practical Center of Mental Health, Pavlodar 140002, Kazakhstan;

关键词: octodrine;    dimethylhexylamine;    DMHA;    ambredin;    fitness;    novel psychoactive substance;    performance and image-enhancing drugs;    anti-obesity agents;    weight loss;   

DOI  :  10.3390/brainsci8020034

来源: DOAJ

【 摘 要 】

Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine’s synonyms and chemical isomers. Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as “the next big thing” and “the god of stimulants,” with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.

【 授权许可】

Unknown