Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

Emerging Microbes and Infections

Simon Rohner¹  Ursula Siebert¹  Stephanie Gross¹  Luca A. Schick¹  Jana C. Klink¹  Lotte Caecilia Striewe¹  Anne Pohlmann²  Martin Beer²  Jacqueline King²  Timm Harder²  Mara Sophie Lombardo³  Wencke Reineking³  Madeleine de le Roi³  Wolfgang Baumgärtner³  Alexander Postel⁴  Johanna Kennedy⁴  Paul Becher⁴  Katharina Kramer⁵  Guus Rimmelzwaan⁶  Albert D. M. E. Osterhaus⁶  Franziska K. Kaiser⁶  Thomas Gerlach⁶ 

[1]Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine

[2]Institute of Diagnostic Virology, Friedrich-Loeffler-Institute

[3]Institute of Pathology, University of Veterinary Medicine

[4]Institute of Virology, University of Veterinary Medicine

[5]Landeslabor Schleswig- Holstein, Neumünster, Germany

[6]University of Veterinary Medicine

关键词: influenza virus;    hpaiv;    h5n8;    avian;    seal;    mammal;    brain;    lung;   

DOI  :  10.1080/22221751.2022.2043726

来源: DOAJ

【 摘 要 】

In brain tissue of three harbor seals of the German North Sea Coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627 K variants detected in these cases.

【 授权许可】

Unknown