Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Advanced Science

Vahid Jahed¹  Matineh Ghomi²  Pooyan Makvandi²  Uros Josic³  Lorenzo Breschi³  Tarun Agarwal⁴  Tapas Kumar Maiti⁴  Masoud Delfi⁵  Filippo Rossi⁶  Filippo Pinelli⁶  Emine Kaya⁷  Milad Ashrafizadeh⁸  Atefeh Zarepour⁹  Ali Zarrabi⁹  Ehsan Nazarzadeh Zare^1,10  Franklin R Tay^1,11 

[1] Biomedical Engineering Division, Faculty of Chemical Engineering Tarbiat Modares University Tehran Iran;Chemistry Department, Faculty of Science Shahid Chamran University of Ahvaz Ahvaz 6153753843 Iran;Department of Biomedical and Neuromotor Sciences University of Bologna Via San Vitale 59 Bologna 40125 Italy;Department of Biotechnology Indian Institute of Technology Kharagpur Kharagpur West Bengal 721302 India;Department of Chemical Sciences University of Naples “Federico II” Complesso Universitario Monte S. Angelo, Via Cintia Naples 80126 Italy;Department of Chemistry, Materials and Chemical Engineering Politecnico di Milano Technical University Milano 20133 Italy;Faculty of Dentistry Istanbul Okan University Tuzla Campus Tuzla Istanbul 34959 Turkey;Faculty of Engineering and Natural Sciences Sabanci University Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı Tuzla Istanbul 34956 Turkey;Sabanci University Nanotechnology Research and Application Center (SUNUM) Tuzla Istanbul 34956 Turkey;School of Chemistry Damghan University Damghan 36716–41167 Iran;The Dental College of Georgia Augusta University 1430 John Wesley Gilbert Drive Augusta GA 30192 USA;

关键词: antibacterial;    antiviral;    drug delivery;    oral cancer;    tissue regeneration;   

DOI  :  10.1002/advs.202004014

来源: DOAJ

【 摘 要 】

Abstract The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally‐administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically‐administered medications, drug resistance and adverse side‐effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle‐containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug‐release platforms than conventional treatment approaches. The present review provides an overview of newly‐developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

【 授权许可】

Unknown