A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

Molecules

Bin Yang¹  Xuefeng Zhou¹  Juan Liu¹  Jianglian She²  Xiliang Yang²  Jingxia Huang³ 

[1] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science of Technology, Wuhan 430081, China;Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China;

关键词: marine fungus;    Penicillium sp.;    penixanthone;    macrodiolide;    chromone;   

DOI  :  10.3390/molecules24091686

来源: DOAJ

【 摘 要 】

A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4−7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1−7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.

【 授权许可】

Unknown