Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

Marine Drugs

Takashi Kikuchi¹  Tomoya Hirano¹  Takeshi Yamada¹  Minami Kataoka¹  Haruka Kogure¹ 

[1] Department of Medicinal Molecular Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan;

关键词: macrodiolide;    14-membered ring;    Halosphaeriaceae sp.;    Sargassum thunbergii;    colletodiol;    cytotoxicity;   

DOI  :  10.3390/md18060320

来源: DOAJ

【 摘 要 】

Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia, human HL-60 leukemia, and murine L1210 leukemia cell lines, with IC₅₀ values ranging from 2.2 ± 3.1 to 11.7 ± 2.8 μM.

【 授权许可】

Unknown