Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials

Coatings

Andreas Blennow¹  John Duncan²  Jinchuan Xu³  Domenico Sagnelli³  Steve Howdle³  Vincenzo Taresco³  SadieM. E. Swainson⁴  Robert Cavanagh⁴ 

[1] Department of Plant and Environment Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark;Lacerta Technology, Shepshed, Loughborough LE12 9GX, UK;School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK;School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK;

关键词: starch;    nanoparticles;    biomaterial;    biocompatible;    Caco-2;    polyglycerol adipate;    DMA;    composites;    polymer synthesis;   

DOI  :  10.3390/coatings9080482

来源: DOAJ

【 摘 要 】

Starch is one of the most abundant polysaccharides on the earth and it is the most important source of energy intake for humans. Thermoplastic starch (TPS) is also widely used for new bio-based materials. The blending of starch with other molecules may lead to new interesting biodegradable scaffolds to be exploited in food, medical, and pharmaceutical fields. In this work, we used native starch films as biopolymeric matrix carriers of chemo enzymatically-synthesized poly (glycerol-adipate) (PGA) nanoparticles (NPs) to produce a novel and biocompatible material. The prototype films had a crystallinity ranging from 4% to 7%. The intrinsic and thermo-mechanical properties of the composite showed that the incorporation of NPs in the starch films decreases the glass transition temperature. The utilization of these film prototypes as the basis for new biocompatible material showed promise, particularly because they have a very low or even zero cytotoxicity. Coumarin was used to monitor the distribution of the PGA NPs in the films and demonstrated a possible interaction between the two polymers. These novel hybrid nanocomposite films show great promise and could be used in the future as biodegradable and biocompatible platforms for the controlled release of amphiphilic and hydrophobic active ingredients.

【 授权许可】

Unknown