Vulvar glomangioma: A case report and literature review

Gynecologic Oncology Reports

Ali D. Tahbouh Amawi¹  Amanika Kumar²  Jorge Torres-Mora²  Sudhakar K. Venkatesh³  Ellen West³  Kyle E. Robinson⁴ 

[1] Mayo Clinic Florida, Jacksonville, FL, USA;Mayo Clinic, Rochester, MN, USA;Department of Radiology;Mayo Clinic Alix School of Medicine;

关键词: Vulvar neoplasm;    GLMN gene;    Glomangioma;   

DOI  :  

来源: DOAJ

【 摘 要 】

GLMN is a gene that encodes a critical protein necessary for normal vascular development. Mutations of GLMN predispose individuals to development of glomangiomas, with nearly 100% penetrance by age 30. Glomangiomas are tumors of the glomus body, a thermoregulatory arterial-venous shunt composed of modified smooth muscle cells. Vulvar glomangioma is an exceedingly rare cause of chronic pelvic pain, that may be easily confused for other conditions such as Bartholin’s gland abscess or deep angiomxyomas, thereby delaying diagnosis and treatment. Glomangiomas have characteristic pathologic and imaging findings which may aid diagnosis. We herein describe the case of a 24-year-old female who developed chronic pelvic pain in the setting of a vulvar glomangioma. We further delineate the magnetic resonance imaging and biopsy findings critical to her diagnosis, and the appropriate steps taken for surgical management. She was found to harbor a heterozygous GLMN mutation. To the best of our knowledge, this is the first description of such a case in the medical literature.

【 授权许可】

Unknown