Autopsy findings of a patient with severe COVID-19 treated with long-term extracorporeal membrane oxygenation

Respiratory Medicine Case Reports

Kaoru Yoshikawa¹  Hideki Miyazaki²  Akio Kimura²  Tatsuya Okamoto²  Fumito Kato³  Mayu Sugiyama³  Toru Igari³  Koichiro Tomiyama³  Keigo Sekihara³  Takatoshi Shibasaki³  Tatsuki Uemura³ 

[1] Corresponding author. Department of Intensive Care Medicine, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku, Tokyo, 162-8655, Japan.;Department of Emergency Medicine and Critical Care, Center Hospital of the National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan;Department of Intensive Care Medicine, Center Hospital of the National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan;

关键词: Autopsy pathology;    COVID-19;    Diffuse alveolar damage;    Extracorporeal membrane oxygenation;    Pulmonary hemorrhage;    SARS-CoV-2;   

DOI  :  

来源: DOAJ

【 摘 要 】

Extracorporeal membrane oxygenation (ECMO) therapy in patients with coronavirus disease 2019 (COVID-19) has a low frequency of use, and thus pathological findings in such patients are valuable. In this case report, a 62-year-old man with a history of hypertension presented with a runny nose. After an at-home COVID-19 positive test, he developed dyspnea and fever. Once admitted to our hospital, his oxygenation worsened, and ECMO was initiated. He died from respiratory failure 69 days after ECMO induction. Macroscopically, the lungs gained mass, were partially consolidated, and were airless. Histological analysis revealed diffuse bronchial epithelial metaplasia and adenoid metaplasia in the alveolar epithelium. Although the lung parenchyma was partially preserved, there was organizing and fibrosis that filled pulmonary alveolus due to COVID-19 and changes resulting from disuse and long-term ECMO.

【 授权许可】

Unknown