Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial

Journal of Clinical Medicine

Alyssa Franzese¹  JenniferM. Jones¹  LianneB. Dolan¹  ShabbirM. H. Alibhai¹  Eugene Chang¹  Darren Au²  Encarna Camacho Pérez²  Daniel Santa Mina²  JeffreyH. Lipton³ 

[1] Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada;Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada;Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada;

关键词: exercise;    stem cell transplant;    cancer;    oncology;    rehabilitation;    prehabilitation;   

DOI  :  10.3390/jcm9061854

来源: DOAJ

【 摘 要 】

People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT) experience significant deconditioning that can compromise quality of life. Exercise has shown to be beneficial before or after allo-HSCT; however, little is known about exercise therapy delivered across the continuum of care. We conducted a feasibility randomized controlled trial of exercise delivered prior to admission, during the inpatient stay, and after discharge versus control in people with planned allo-HSCT. Feasibility was assessed via recruitment and retention rates, the incidence of adverse events, and adherence to the exercise prescription. Estimates of efficacy were measured at baseline, one week prior to hospital admission, and 100 days and one year after transplant. The recruitment and retention rates were 20% and 33%, respectively. One serious adverse event occurred during the baseline six-minute walk test that precluded participation in the study and no adverse events were associated with the intervention. From baseline to pre-transplant, the intervention group improved six-minute walk test distances by 45 m (95% CI: −18.0 to 108.7)—a finding that warrants further investigation with an adequately powered trial. Our study contributes important feasibility considerations and pilot data for future exercise intervention research in allo-HSCT recipients.

【 授权许可】

Unknown