Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study

Sustainability

Marius Rus¹  Simona Bungau²  DeliaMirela Tit²  Abbas Rahdar³  Nicoleta Negrut⁴  DeliaCarmen Nistor-Cseppento⁴  Octavian Maghiar⁵  Carmen Pantis⁵  TeodorAndrei Maghiar⁵  ShamimAhmad Khan⁶  Selim Aleya⁷  Lotfi Aleya⁸ 

[1] Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania;Department of Physics, University of Zabol, Zabol 98613-35856, Iran;Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania;Faculty of Medicine, Université de Franche-Comté, 25000 Besançon, France;Université de Franche-Comté, Chrono-environment CNRS 6249, 25000 Besançon, France;

关键词: Clostridium difficile infection;    epidemiology;    proton-pump inhibitors;    antidepressants;    Romania;   

DOI  :  10.3390/su12114439

来源: DOAJ

【 摘 要 】

Clostridium difficile infection (CDI) is the most common infectious disease related to antibiotic-associated diarrhoea and is a current leading cause of morbidity/mortality, with substantial consequences for healthcare services and overall public health. Thus, we performed a retrospective epidemiological study of CDI for a long period (8 years), in an infectious hospital located in north-western Romania, which serves an entire county of the country (617,827 inhabitants). From 2011 to 2018, 877 patients were diagnosed with CDI; the mean incidence of this disease was 2.76 cases/10,000 patient-days, with an increasing trend in the annual incidence until 2016, at which point there was a decrease. The most commonly afflicted were patients in the 75–84 age group, observed in winter and spring. The results show that the antibiotics were administered in 679 (77.42%) subjects, within the last 3 months before CDI, statistically significant more than proton-pump inhibitors (PPIs)—128 (14.60%) and antidepressant medications—60 (6.84%), which were administered during the same period (p < 0.001). No medication was reported in 10 (6.84%) cases of CDI, in the last 3 months of the study. The fatality rate attained 4.1%, tripling in 2018 vs. 2011. CDI became a significant public health conundrum that can, nevertheless, be combatted through a judicious use of antibiotics.

【 授权许可】

Unknown