Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review

Nutrients

Benjamin Lebwohl¹  Stefanie Puglielli²  AllieB. Cichewicz²  ElizabethS. Mearns²  KellyJ. Thomas Craig²  DavidS. Sanders³  Marios Hadjivassiliou³  Aliki Taylor⁴  DanielA. Leffler⁵ 

[1] Department of Medicine, Celiac Disease Center, Columbia University Medical Center, New York, NY 10032, USA;IBM Watson Health, Cambridge, MA 02142, USA;Royal Hallamshire Hospital and University of Sheffield, Sheffield S10 2RX, UK;Takeda Development Centre Europe Ltd., London WC2B 4AE, UK;Takeda Pharmaceuticals International Co, Cambridge, MA 02139, USA;

关键词: celiac disease;    gluten neuropathy;    gluten ataxia;    prevalence;    incidence;    gluten-free diet;   

DOI  :  10.3390/nu11020380

来源: DOAJ

【 摘 要 】

Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. MEDLINE, Embase, the Cochrane Library, and conference proceedings were systematically searched from January 2007 through September 2018. Included studies evaluated patients with CD with at least one neurological manifestation of interest and reported prevalence, and/or incidence, and/or clinical outcomes. Sixteen studies were included describing the risk of gluten neuropathy and/or gluten ataxia in patients with CD. Gluten neuropathy was a neurological manifestation in CD (up to 39%) in 13 studies. Nine studies reported a lower risk and/or prevalence of gluten ataxia with a range of 0%⁻6%. Adherence to a gluten-free diet appeared to improve symptoms of both neuropathy and ataxia. The prevalence of gluten neuropathy and gluten ataxia in patients with CD varied in reported studies, but the increased risk supports the need for physicians to consider CD in patients with ataxia and neurological manifestations of unknown etiology.

【 授权许可】

Unknown