Autism spectrum disorder and celiac disease: no evidence for a link

Arquivos de Neuro-Psiquiatria

Icaro Camargo Batista²  Lenora Gandolfi¹  Yanna Karla Medeiros Nobrega¹  Rodrigo Coutinho Almeida¹  Lucas Malta Almeida¹  Dioclécio Campos Junior²  Riccardo Pratesi¹ 

[1] ,University of Brasília School of Health Sciences Brasília DF ,Brazil

关键词: autistic spectrum disorder;    celiac disease;    prevalence;    mass screening;    transtorno autístico;    doença celíaca;    prevalência;    programa de rastreamento;   

DOI  :  10.1590/S0004-282X2012000100007

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the possible association between celiac disease (CD) and/or gluten sensitivity (GS) and autism spectrum disorder (ASD). METHODS: Occurrences of CD were determined in a group of children and adolescents affected by ASD and, conversely, occurrences of ASD were assessed in a group of biopsy-proven celiac patients. To detect the possible existence of GS, the levels of antigliadin antibodies in ASD patients were assessed and compared with the levels in a group of non-celiac children. RESULTS: The prevalence of CD or GS in ASD patients was not greater than in groups originating from the same geographical area. Similarly the prevalence of ASD was not greater than in a group of biopsy-proven CD patients. CONCLUSION: No statistically demonstrable association was found between CD or GS and ASD. Consequently, routine screening for CD or GS in all patients with ASD is, at this moment, neither justified nor cost-effective.

【 授权许可】

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