The Roles of Neurotrophins in Traumatic Brain Injury

Life

Ping-Hung Lin¹  Hui-Tzung Luh²  Lu-Ting Kuo³ 

[1] Department of Medical Education, School of Medicine, National Taiwan University, Taipei 100, Taiwan;Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan;Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan;

关键词: neurotrophins;    traumatic brain injury;    nerve growth factor;    brain-derived neurotrophic factor;    NT-3;    NT-4/5;   

DOI  :  10.3390/life12010026

来源: DOAJ

【 摘 要 】

Neurotrophins are a collection of structurally and functionally related proteins. They play important roles in many aspects of neural development, survival, and plasticity. Traumatic brain injury (TBI) leads to different levels of central nervous tissue destruction and cellular repair through various compensatory mechanisms promoted by the injured brain. Many studies have shown that neurotrophins are key modulators of neuroinflammation, apoptosis, blood–brain barrier permeability, memory capacity, and neurite regeneration. The expression of neurotrophins following TBI is affected by the severity of injury, genetic polymorphism, and different post-traumatic time points. Emerging research is focused on the potential therapeutic applications of neurotrophins in managing TBI. We conducted a comprehensive review by organizing the studies that demonstrate the role of neurotrophins in the management of TBI.

【 授权许可】

Unknown