Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle

Frontiers in Physiology

Fernanda Pinto-Mariz²  Claudia F. Benjamim⁴  Adriana C. Bonomo⁵  Wilson Savino⁵  Ingo Riederer⁶  Gillian Butler-Browne⁷  Vincent Mouly⁷ 

[1] Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;Marzagão Gesteira Institute of Pediatrics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;Program of Immunobiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Rio de Janeiro Research Network on Neuroinflammation (RENEURIN), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil;School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, United Kingdom;Sorbonne Université, Inserm, Institut de Myologie, U974, Center for Research in Myology, Paris, France;

关键词: myoblasts;    macrophages;    dendritic cells;    effector T cells;    regulatory T cells;    polymyositis;   

DOI  :  10.3389/fphys.2020.573347

来源: DOAJ

【 摘 要 】

Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal muscle regeneration. Although one component of the innate immunity, the macrophage, has been extensively studied both in disease conditions and during cell or gene therapy strategies aiming at restoring muscular functions, much less is known about dendritic cells and their primary immunological targets, the T lymphocytes. This review will focus on the dendritic cells and T lymphocytes (including effector and regulatory T-cells), emphasizing the potential cross talk between these cell types and their influence on the structure and function of skeletal muscle.

【 授权许可】

Unknown