Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery

Molecules

Chenyu Wang¹  Haopeng Zhu²  Guangqing Gai²  Liyan Wang²  Bozhong Lin²  Shanshan Xiao²  Li Zhao²  Fei Bi² 

[1] Department of Orthopedics, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do 200-702, Korea;Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China;

关键词: phenylboronic acid;    gel;    glucose sensitivity;    drug delivery;    diabetes therapy;   

DOI  :  10.3390/molecules24061089

来源: DOAJ

【 摘 要 】

Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy.

【 授权许可】

Unknown