Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Materials

Yangyang Liu¹  Qiongwei Huang²  Qing Wang²  Jianxun Ding³  Liyan Wang⁴  Shanshan Xiao⁴  Li Zhao⁴  Fei Bi⁴ 

[1] Department of Endocrine, the First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130117, China;Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130033, China;Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China;

关键词: phenylboronic acid;    glucose-sensitivity;    drug delivery;    diabetes therapy;   

DOI  :  10.3390/ma10020170

来源: DOAJ

【 摘 要 】

In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.

【 授权许可】

Unknown