Acrylamide Content in Breast Milk: The Evaluation of the Impact of Breastfeeding Women’s Diet and the Estimation of the Exposure of Breastfed Infants to Acrylamide in Breast Milk

Toxics

Włodzimierz Sawicki¹  Joanna Winiarek¹  Iwona Gielecińska²  Hanna Mojska³ 

[1] Chair and Department of Obstetrics, Gynecology and Gynecological Oncology of Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland;Department of Food Safety, National Institute of Public Health, NIH-National Research Institute, Chocimska 24, 00-791 Warsaw, Poland;Department of Nutrition and the Nutritive Value of Food, National Institute of Public Health-NIH-National Research Institute, Chocimska 24, 00-791 Warsaw, Poland;

关键词: breast milk;    acrylamide;    LC–MS/MS;    infants;    exposure;   

DOI  :  10.3390/toxics9110298

来源: DOAJ

【 摘 要 】

Acrylamide in food is formed by the Maillard reaction. Numerous studies have shown that acrylamide is a neurotoxic and carcinogenic compound. The aim of this study was to determine the level of acrylamide in breast milk at different lactation stages and to evaluate the impact of breastfeeding women’s diet on the content of this compound in breast milk. The acrylamide level in breast milk samples was determined by LC–MS/MS. Breastfeeding women’s diet was evaluated based on the 24 h dietary recall. The median acrylamide level in colostrum (n = 47) was significantly (p < 0.0005) lower than in the mature milk (n = 26)—0.05 µg/L and 0.14 µg/L, respectively. The estimated breastfeeding women’s acrylamide intake from the hospital diet was significantly (p < 0.0001) lower than that from the home diet. We found positive—although modest and borderline significant—correlation between acrylamide intake by breastfeeding women from the hospital diet µg/day) and acrylamide level in the colostrum (µg/L). Acrylamide has been detected in human milk samples, and a positive correlation between dietary acrylamide intake by breastfeeding women and its content in breast milk was observed, which suggests that the concentration can be reduced. Breastfeeding women should avoid foods that may be a source of acrylamide in their diet.

【 授权许可】

Unknown