TGF-β Concentration in Breast Milk is Associated With the Development of Eczema in Infants

Frontiers in Pediatrics

Fumiya Yamaide¹  Naoki Shimojo¹  Taiji Nakano¹  Eduardo Campos-Alberto¹  Yoshinori Morita¹  Yoichi Kohno¹  Naomi Kondo²  Norio Kawamoto²  Eiko Matsui²  Minako Kawamoto²  Hidenori Ohnisi² 

[1] Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan;Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan;

关键词: TGF-β;    breast milk;    infants;    allergy;    eczema;   

DOI  :  10.3389/fped.2018.00162

来源: DOAJ

【 摘 要 】

Background: Transforming growth factor (TGF)-β in breast milk is crucial for mucosal immune system in the neonatal period. We hypothesized that the level of exposure to TGF-β from breast milk in the first month of life is related to the development of eczema later in life. Thus, the present study investigated whether changes in TGF-β levels between colostrum and mature milk are associated with such occurrence in a birth cohort study.Methods: Colostrum and 1-month breast milk samples were collected from mothers who participated in our birth cohort study. TGF-β1 and TGF-β2 levels in breast milk were measured using a commercial ELISA kit. The development of eczema in the first 6 months after birth was assessed based on parent's response to a questionnaire. Levels of TGF-β1 and TGF-β2 were compared in breast milk from mothers of infants with and without eczema.Results: In children with eczema, TGF-β1 levels were higher in colostrum, but lower in 1-month milk. A lower TGF-β1 ratio (1-month milk/colostrum) was related to the development of eczema during the first 6 months of life. There was no difference in TGF-β2 ratio (1-month milk/colostrum) between eczema group and control group.Conclusions: Concentration of TGF-β1 but not TGF-β2 in breast milk during the first month after birth may be associated with eczema later in life. Factors that increase TGF-β1 levels in breast milk may play a role in preventing allergic disease.

【 授权许可】

Unknown