Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature

Journal of Advanced Research

Stefano Sirgiovanni¹  Maria Consuelo Valentini¹  Mario Stanziano¹  Sara Palermo²  Leonardo Lopiano²  Maurizio Zibetti²  Francesca Dematteis²  Rosalba Morese³ 

[1] Azienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Department of Neuroradiology, Corso Bramante 88/90, 10126 Turin, Italy;Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy;Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy;

关键词: Parkinson’s disease;    ICD;    Response-inhibition;    Action monitoring;    fMRI;    ACC;   

DOI  :  10.1016/j.jare.2017.09.004

来源: DOAJ

【 摘 要 】

This report illustrates a Parkinson’s disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD. A fronto-striatal and cingulo-frontal dysfunction may reflect impairment in metacognitive-executive abilities (such as response-inhibition, action monitoring, and error awareness) and promote compulsive repetition of behavior. Response-inhibition tasks may be useful in PD post-diagnostic phase, to better identify individuals at risk of developing ICD with dopaminergic medication.

【 授权许可】

Unknown