Surface Modification of PLLA, PTFE and PVDF with Extreme Ultraviolet (EUV) to Enhance Cell Adhesion

International Journal of Molecular Sciences

Adam Lech¹  Tomasz Ciach¹  BeataA. Butruk-Raszeja¹  Przemyslaw Wachulak²  Henryk Fiedorowicz²  Andrzej Bartnik²  Piotr Kuzmiuk³  Krystyna Lawniczak-Jablonska³ 

[1] Department of Biotechnology and Bioprocess Engineering, Warsaw University of Technology, Warynskiego 1, 00-645 Warsaw, Poland;Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland;Institute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, 02-668 Warsaw, Poland;

关键词: extreme ultraviolet;    surface modification;    surface biocompatibility;    cell adhesion;    PTFE;    PLLA;   

DOI  :  10.3390/ijms21249679

来源: DOAJ

【 摘 要 】

Recently, extreme ultraviolet (EUV) radiation has been increasingly used to modify polymers. Properties such as the extremely short absorption lengths in polymers and the very strong interaction of EUV photons with materials may play a key role in achieving new biomaterials. The purpose of the study was to examine the impact of EUV radiation on cell adhesion to the surface of modified polymers that are widely used in medicine: poly(tetrafluoroethylene) (PTFE), poly (vinylidene fluoride) (PVDF), and poly-L-(lactic acid) (PLLA). After EUV surface modification, which has been performed using a home-made laboratory system, changes in surface wettability, morphology, chemical composition and cell adhesion polymers were analyzed. For each of the three polymers, the EUV radiation differently effects the process of endothelial cell adhesion, dependent of the parameters applied in the modification process. In the case of PVDF and PTFE, higher cell number and cellular coverage were obtained after EUV radiation with oxygen. In the case of PLLA, better results were obtained for EUV modification with nitrogen. For all three polymers tested, significant improvements in endothelial cell adhesion after EUV modification have been demonstrated.

【 授权许可】

Unknown