Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Peng Qiu¹  Pin Wang¹  Min Liu¹  Min Zheng¹  Le Feng¹  Tao Dai¹ 

[1]The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan, China

[2]Luzhou Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Luzhou, Sichuan, China

[3]Institute of Stomatology, Southwest Medical University, Luzhou, Sichuan, China

关键词: polyetheretherketone;    casein phosphopeptide;    surface modification;    cell adhesion;    cell proliferation;    osteoinductive ability;   

DOI  :  10.3389/fbioe.2023.1100238

 received in 2022-11-16, accepted in 2023-01-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Polyetheretherketone (PEEK) is a potential implant material for dental application due to its excellent mechanical properties. However, its biological inertness and poor osteoinductive ability limited its clinical application. Based on a lay-by-layer self-assembly technique, here we incorporated casein phosphopeptide (CPP) onto PEEK surface by a simple two-step strategy to address the poor osteoinductive ability of PEEK implants. In this study, the PEEK specimens were positively charged by 3-ammoniumpropyltriethoxysilane (APTES) modification, then the CPP was adsorbed onto the positively charged PEEK surface electrostatically to obtain CPP-modified PEEK (PEEK-CPP) specimens. The surface characterization, layer degradation, biocompatibility and osteoinductive ability of the PEEK-CPP specimens were studied in vitro. After CPP modification, the PEEK-CPP specimens had a porous and hydrophilic surface and presented enhanced cell adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. These findings indicated that CPP modification could significantly improve the biocompatibility and osteoinductive ability of PEEK-CPP implants in vitro. In a word, CPP modification is a promising strategy for the PEEK implants to achieve osseointegration.

【 授权许可】

Unknown   
Copyright © 2023 Qiu, Wang, Liu, Dai, Zheng and Feng.