A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors

Frontiers in Oncology

Wenming Chen¹  Weidong Chen¹  Gengwei Huo¹  Ying Song²  Ran Zuo³  Peng Chen³  Fuyi Zhu³  Cuicui Zhang³  Yali Wang³  Jinliang Chen³  Jinfang Cui³  Hua Guo⁴ 

[1] Department of Oncology, Jining No.1 People’s Hospital, Jining, China;Department of Pharmacy, Jining No.1 People’s Hospital, Jining, China;Department of Thoracic Oncology, Lung Cancer Diagnosis and Treatment Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, China;Department of Tumor Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;

关键词: TWF1;    cancer;    prognosis;    phosphorylation;    survival;   

DOI  :  10.3389/fonc.2021.692136

来源: DOAJ

【 摘 要 】

BackgroundUnderstanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene in lung cancer, pancreatic cancer and breast cancer, however a systematic pan-cancer analysis has not been carried out.MethodsHere, we set out to explore the role of TWF1 in 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Protein Atlas (HPA), and several bioinformatic tools.ResultsAs part of our analysis, we have assessed TWF1 expression across tumors. We found that over-expression of TWF1 generally predicted poor OS for patients with tumors with high TWF1 expression, such as mesothelioma, lung adenocarcinoma, cervical cancer and pancreatic adenocarcinoma. We also assessed the mutation burden of TWF1 in cancer and the TWF1-associated survival of cancer patients, compared the phosphorylation of TWF1 between normal and primary tumor tissues and explored putative functional mechanisms in TWF1-mediated oncogenesis.ConclusionsOur pan-cancer analysis provides a comprehensive overview of the oncogenic roles of TWF1 in multiple human cancers.

【 授权许可】

Unknown