Bromopyrrole alkaloids from the caribbean sponge Agelas cerebrum

Química Nova

Erik L. Regalado¹  Abilio Laguna¹  Judith Mendiola²  Clara Nogueiras³  Olivier P. Thomas⁴ 

[1] Center of Marine Bioproducts, Loma y 37;Instituto de Medicina Tropical Pedro Kourí;Universidad de La Habana;Université de Nice-Sophia Antipolis;

关键词: Agelas cerebrum;    bromopyrrole alkaloids;    antitumoral and antiprotozoal activity;   

DOI  :  10.1590/S0100-40422011000200022

来源: DOAJ

【 摘 要 】

Bioguided fractionation of Agelas cerebrum crude extract resulted in isolation of four bromopyrrole and four bromopyrrole aminoimidazole alkaloids, identified as 5-bromopyrrole-2-carboxylic acid (1), 4-bromopyrrole-2-carboxylic acid (2), 3,4-bromopyrrole-2-carboxylic acid (3), 4,5-bromopyrrole-2-carboxylic acid (4), oroidin (5), bromoageliferin (6), dibromoageliferin (7) and dibromosceptrin (8) on the basis of spectroscopic data analyses (UV, IR, HRMS, 1D and 2D NMR) and comparison with literature data. This is the first report of compounds 2 and 3 in a marine sponge belonging to the Agelas genus and the first evidence of the presence of 1 from a natural source.

【 授权许可】

Unknown