Bromopyrrole alkaloids from the caribbean sponge Agelas cerebrum

Química Nova

Regalado, Erik L.¹  Institute of Tropical Medicine Pedro Kourí, Havana, Cuba¹  Laguna, Abilio¹  Center of Marine Bioproducts, Loma y 37, Havana, Cuba¹  Université de Nice-Sophia Antipolis, France¹  Thomas, Olivier P.¹  Mendiola, Judith¹  University of Havana, Havana, Cuba¹  Nogueiras, Clara¹ 

关键词: Agelas cerebrum;    bromopyrrole alkaloids;    antitumoral and antiprotozoal activity.;   

DOI  :  10.1590/S0100-40422011000200022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Bioguided fractionation of Agelas cerebrum crude extract resulted in isolation of four bromopyrrole and four bromopyrrole aminoimidazole alkaloids, identified as 5-bromopyrrole-2-carboxylic acid (1), 4-bromopyrrole-2-carboxylic acid (2), 3,4-bromopyrrole-2-carboxylic acid (3), 4,5-bromopyrrole-2-carboxylic acid (4), oroidin (5), bromoageliferin (6), dibromoageliferin (7) and dibromosceptrin (8) on the basis of spectroscopic data analyses (UV, IR, HRMS, 1D and 2D NMR) and comparison with literature data. This is the first report of compounds 2 and 3 in a marine sponge belonging to the Agelas genus and the first evidence of the presence of 1 from a natural source.

【 授权许可】

Unknown